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PIRACETAM (Nootropil ®)

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Legal Disclaimer

FDA has not approved drugs containing racetams, including piracetam, for use in the United States. The U.S. Food and Drug Administration deems such compounds as prescription drugs because of their toxicity and potential harmful effect.

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PIRACETAM (NOOTROPIL) INFORMATION

Chemical name: 2-(2-oxopyrrolidin-1-yl) acetamide
Form: pills 1200 mg / pills 800 mg / ampoules 5 ml, 200 mg/ml
Trade names: Nootropil, Lucetam, Nootropyl, Piracetam, 2-(2-Oxopyrrolidino) acetamide, 2-Oxo-1-pyrrolidine acetamide
CAS Number: 7491-74-9
Molecular formula: C6H10N2O2
ATC code: N06BX03
Pharmacological action: Nootropic, anti-hypoxic, cerebroprotective
Shelf life: 3 years. Do not use beyond the expiration date printed on the package.
Storage conditions: Store in a dry dark place at temperatures no higher than 30°C. Keep out of reach of children.
Manufacturer: UCB Pharma (Belgium), www.ucb-group.com

 

WHAT IS PIRACETAM?

Piracetam is a nootropic supplement that is used to improve cognitive function. It is a derivative of gamma-amino-butyric acid (GABA) with an effect on the central nervous system (CNS). Piracetam is also used in the complex therapy of medical conditions with brain function impairment.

Piracetam was first created in 1964 by a team of scientists under the guidance of Dr Giurgea. It is often called “the grandfather of all nootropics”.

Over the last four decades, Piracetam under the brand name Nootropil has been extensively studied and it is currently approved for use in over 100 countries.

PIRACETAM (NOOTROPIL) RESEARCH

Piracetam clinical studies and research focus on the elderly with dementia, schizophrenia, and other related neurodegenerative and cognitive disorders, or brain injury cases. Go to the Research tab for links to scientific papers including animal and human studies.

WHAT ARE PIRACETAM BENEFITS & EFFECTS?

Piracetam is a nootropic supplement that is used to improve cognitive function. It is believed to help with memory, learning, focus, and concentration. Some people also take Piracetam to help with anxiety and depression.

Piracetam is often used by healthy individuals searching for safe and mild cognitive improvement. But it is mostly prescribed to older patients, children, and adults who want to relieve the following symptoms:

  • Symptomatic treatment of various memory disorders;
  • Psychoorganic syndrome with asthenia;
  • Alcoholic psycho-organic syndrome;
  • Treatment-resistant depressions;
  • Other conditions, characterized by lowered intellectual functioning.

Piracetam’s effects also include preventing blood clotting issues, increasing longevity, and maintaining mental abilities in older patients. It was also found to improve communication between the two hemispheres of the brain.

PIRACETAM (NOOTROPIL) SAFETY

Piracetam (Nootropil) is deemed to be safe and well-tolerated by most users. Piracetam reviews are available in the Reviews tab.

WHERE TO BUY PIRACETAM (NOOTROPIL)?

Piracetam is a popular nootropic supplement that is available for purchase from different vendors. You can order Piracetam OTC in some countries. There are different forms of Piracetam available to source: powder, pills, solution. CosmicNootropic offers Piracetam capsules and ampoules in the US and worldwide.

Also check out Piracetam combination nootropics:

  • OMARON [Piracetam + Cinnarizine] to stimulate neuronal metabolism and benefit from nootropic effects
  • VINPOTROPILE [Vinpocetine + Piracetam] to improve cerebral blood flow and cognitive functions

Legal Disclaimer
This product has not been approved by the US FDA. All statements on this page are for informational purposes only and have not been evaluated by the US FDA.
This product is not intended to diagnose, treat, cure, or prevent any disease. See more

HOW TO USE PIRACETAM (NOOTROPIL)?

Nootropil Pills

The standard Piracetam dosage is 1,200mg / two times a day, which is 2,400 mg in total. The dosing of Piracetam depends on the person’s condition and the desired effects.

If oral administration is not possible, for example in case of unconsciousness or swallowing problems, doctor can prescribe nootropil / piracetam injections.

Nootropil Injections

Before injecting, the drug shall be diluted in one of the matching infusion solutions.

For cognition-related issues, piracetam injection dosage is 2.4-4.8 grams/daily. When treating alcohol withdrawal symptoms the dosage can be increased up to 9–12 g. The daily dose is divided into several injections at regular intervals so that the dose per injection would not exceed 3 g.

For more instructions on Piracetam doses please refer to the translated official drug sheets following the links below.

Nootropil Course Duration

One pack of Nootropil contains 20 pills, each with 1200 mg of the active ingredient. This amount is sufficient for an average of 10 days of supplementation.

If Piracetam is used as a mild cognitive enhancer by otherwise healthy people it shall be normally taken for a period from 4 to 6 weeks, with main effects starting to manifest after 3-4 weeks of supplementation.

WHAT ARE PIRACETAM SIDE EFFECTS?

Piracetam is a nootropic that has been studied extensively. Side effects occur rarely, with the most common being increased irritability, hyperkinesia (excessive abnormal movements), and body weight gain.

Check with your doctor before taking Piracetam if you are pregnant, breastfeeding, have renal impairment, or any other medical conditions.

You can find more information here.

 

OFFICIAL INSTRUCTION – Piracetam Injections

OFFICIAL INSTRUCTION – Piracetam Pills

  1. CBartus et al (1981) Profound effects of combining choline and piracetam on memory enhancement and cholinergic function in aged rats https://www.ncbi.nlm.nih.gov/pubmed/7301036
  2. Wilsher et al (1987) Piracetam and dyslexia: effects on reading tests https://www.ncbi.nlm.nih.gov/pubmed/3305591
  3. Mondadori et al (1989) The memory-enhancing effects of the piracetam-like nootropics are dependent on experimental parameters https://www.ncbi.nlm.nih.gov/pubmed/2736062
  4. Sano et al (1990) A controlled trial of piracetam in intellectually impaired patients with Parkinson’s disease https://www.ncbi.nlm.nih.gov/pubmed/2388639
  5. M Vernon, E Sorokin (1991) Piracetam. An overview of its pharmacological properties and a review of its therapeutic use in senile cognitive disorders https://www.ncbi.nlm.nih.gov/pubmed/1794001
  6. Croisile et al (1993) Long-term and high-dose piracetam treatment of Alzheimer’s disease https://www.ncbi.nlm.nih.gov/pubmed/8437693
  7. Enderby et al (1994) Effect of piracetam on recovery and rehabilitation after stroke: a double-blind, placebo-controlled study https://www.ncbi.nlm.nih.gov/pubmed/9316679
  8. A Gouliaev, A Senning (1994) Piracetam and other structurally related nootropics https://www.ncbi.nlm.nih.gov/pubmed/8061686
  9. el-Hazmi et al (1996) Piracetam is useful in the treatment of children with sickle cell disease https://www.ncbi.nlm.nih.gov/pubmed/8922488
  10. Burd et al (1997) Nootropil in the treatment of disorders of the higher mental functions in patients with an ischemic stroke https://www.ncbi.nlm.nih.gov/pubmed/9424344
  11. De Deyn (1997) Treatment of acute ischemic stroke with piracetam. Members of the Piracetam in Acute Stroke Study (PASS) Group https://www.ncbi.nlm.nih.gov/pubmed/9412612
  12. Koskiniemi et al (1998) Piracetam relieves symptoms in progressive myoclonus epilepsy: a multicentre, randomised, double blind, crossover study comparing the efficacy and safety of three dosages of oral piracetam with placebo https://www.ncbi.nlm.nih.gov/pubmed/9527146
  13. Kondakor et al (1999) Single-dose piracetam effects on global complexity measures of human spontaneous multichannel EEG https://www.ncbi.nlm.nih.gov/pubmed/10555876
  14. S Evers, K Grotemeyer (1999) Piracetam and platelets–a review of laboratory and clinical data https://www.ncbi.nlm.nih.gov/pubmed/10338108
  15. Gualtieri et al (2002) Design and study of piracetam-like nootropics, controversial members of the problematic class of cognition-enhancing drugs https://www.ncbi.nlm.nih.gov/pubmed/11812254
  16. Waegemans et al (2002) Clinical efficacy of piracetam in cognitive impairment: a meta-analysis https://www.ncbi.nlm.nih.gov/pubmed/12006732
  17. G Hofmeyr, R Kulier (2002) Piracetam for fetal distress in labour https://www.ncbi.nlm.nih.gov/pubmed/11869588
  18. Uebelhack et al (2003) Effect of piracetam on cognitive performance in patients undergoing bypass surgery https://www.ncbi.nlm.nih.gov/pubmed/12806565
  19. B Winblad (2005) Piracetam: a review of pharmacological properties and clinical uses https://www.ncbi.nlm.nih.gov/pubmed/16007238
  20. Keil et al (2006) Piracetam improves mitochondrial dysfunction following oxidative stress https://www.ncbi.nlm.nih.gov/pubmed/16284628
  21. Libov et al (2007) Efficacy of piracetam in the treatment of tardive dyskinesia in schizophrenic patients: a randomized, double-blind, placebo-controlled crossover study https://www.ncbi.nlm.nih.gov/pubmed/17685739
  22. Mukhin et al (2007) A use of high dosages of piracetam in the treatment of Kozhevnikov epilepsy syndrome https://www.ncbi.nlm.nih.gov/pubmed/18379510
  23. G Neznamov, E Teleshove (2009) Comparative studies of Noopept and piracetam in the treatment of patients with mild cognitive disorders in organic brain diseases of vascular and traumatic origin https://www.ncbi.nlm.nih.gov/pubmed/19234797
  24. A Malykh, M Sadaie (2010) Piracetam and piracetam-like drugs: from basic science to novel clinical applications to CNS disorders https://www.ncbi.nlm.nih.gov/pubmed/20166767
  25. Fang et al (2013) Effect of piracetam on the cognitive performance of patients undergoing coronary bypass surgery: A meta-analysis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881046/
  26. Zhang et al (2016) Piracetam for Aphasia in Post-stroke Patients: A Systematic Review and Meta-analysis of Randomized Controlled Trials https://www.ncbi.nlm.nih.gov/pubmed/27236454
  27. Dolatabadi et al (2019) Oral Piracetam vs Betahistine in Outpatient Management of Peripheral Vertigo; a Randomized Clinical Trial https://pubmed.ncbi.nlm.nih.gov/30847444/ 
  28. K Sivalingam, T amikkannu (2020) Neuroprotective Effect of Piracetam against Cocaine-Induced Neuro Epigenetic Modification of DNA Methylation in Astrocytes https://pubmed.ncbi.nlm.nih.gov/32899583/ 
  29. Zongfang et al (2020) Therapeutic effect of piracetam with nimodipine on vascular dementia after cerebral infarction https://pubmed.ncbi.nlm.nih.gov/33832882/ 
  30. Demiröz et al (2021) Comparison of Ischemic Preconditioning and Systemic Piracetam for Prevention of Ischemia-Reperfusion Injury in Musculocutaneous Flaps https://pubmed.ncbi.nlm.nih.gov/32971545/
  31. Krishnappa et al (2021) Unique Severe HyperEkplexia-Like Apneic Events (SHELAE) Improved by High-Dose Piracetam https://pubmed.ncbi.nlm.nih.gov/34708144/

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